Guy Bush (1923-1934) got his nickname because he came from Mississippi and had a very strange delivery. It was described like this by F.C. Lane in Baseball Magazine (1930): "On the hurling mound (Guy) Bush has developed a curious 'hop-toad' lunge that is unique. When he really bears down on the ball, he actually springs forward and finishes up in a squat position like a catcher reaching for a low pitch."

He won 150+ games for the Cubs, as a starter and reliever (he led the league in relief wins 4 times). On May 4, 1927 he pitched 18 innings in one game, when the Cubs beat the Braves 7-2. He started and won Game 3 of the 1929 World Series against the A's, giving up only one run. He also pitched Game 1 of 1932 Series against the Yankees, but this time the results weren't quite as good. He was shelled for eight earned runs in less than six innings.

The Cubs traded him to Pittsburgh in 1935. Bush always said the secret to his success was a "secret dark liniment" that the Cubs trainer rubbed into his arm. He didn't find out until after he was traded that the secret liniment was only Coca Cola.

On May 25, 1935, he came in as a relief pitcher for the Pirates against the Boston Braves. In that game he gave up the last two home runs in Babe Ruth's career.